Review
doi: 10.1016/j.jocn.2009.11.001.
Epub 2010 Mar 30.
Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus
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- PMID: 20356750
- DOI: 10.1016/j.jocn.2009.11.001
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Review
Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus
J Clin Neurosci.
2010 Jun.
Abstract
The organic anion-transporting polypeptides (rodents: Oatps; human: OATPs) belong to the growing family of organic anion/prostaglandin transporters and are important components of the active efflux transport system at the choroid plexus epithelial cells. OATPs facilitate the elimination of xenobiotics and endogenous waste from the cerebrospinal fluid and prevent waste accumulation in the central nervous system (CNS). This review summarizes the structures, regulations and roles of Oatps/OATPs at the choroid plexus in drug delivery to the CNS.
Copyright 2009 Elsevier Ltd. All rights reserved.
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