Safer CARS
- PMID: 20357776
- PMCID: PMC2862533
- DOI: 10.1038/mt.2010.42
Safer CARS
Comment in
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Is it safer CARs that we need, or safer rules of the road?Mol Ther. 2010 Oct;18(10):1742-3. doi: 10.1038/mt.2010.162. Mol Ther. 2010. PMID: 20885432 Free PMC article. No abstract available.
Comment on
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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.Mol Ther. 2010 Apr;18(4):843-51. doi: 10.1038/mt.2010.24. Epub 2010 Feb 23. Mol Ther. 2010. PMID: 20179677 Free PMC article.
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Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.Mol Ther. 2010 Apr;18(4):666-8. doi: 10.1038/mt.2010.31. Mol Ther. 2010. PMID: 20357779 Free PMC article. No abstract available.
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The promise and potential pitfalls of chimeric antigen receptors.Curr Opin Immunol. 2009 Apr;21(2):215-23. doi: 10.1016/j.coi.2009.02.009. Epub 2009 Mar 25. Curr Opin Immunol. 2009. PMID: 19327974 Free PMC article. Review.
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References
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- Sadelain M, Riviere I., and , Brentjens R. Targeting tumours with genetically enhanced T lymphocytes. Nat Rev Cancer. 2003;3:35–45. - PubMed
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- Lamers CH, Sleijfer S, Vulto AG, Kruit WH, Kliffen M, Debets R, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol. 2006;24:e20–e22. - PubMed
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- Maher J, Brentjens RJ, Gunset G, Riviere I., and , Sadelain M. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol. 2002;20:70–75. - PubMed
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