Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;30(11):751-6.
doi: 10.1038/jp.2010.41. Epub 2010 Apr 1.

Clinical characterization and long-term prognosis of neurological development in preterm infants with late-onset circulatory collapse

H Nakanishi  1 , S Yamanaka, T Koriyama, N Shishida, N Miyagi, T-J Kim, S Kusuda
Affiliations

Clinical characterization and long-term prognosis of neurological development in preterm infants with late-onset circulatory collapse

H Nakanishi et al. J Perinatol. 2010 Nov.

Abstract

Objective: To characterize the risk factors for late-onset circulatory collapse (LCC) in preterm infants responsive to corticosteroid therapy and evaluate the long-term neurological prognosis.

Study design: A retrospective case-control study for preterm infants (≤32 weeks' gestation) admitted to our neonatal intensive care unit from 1994 through 2002.

Result: Sixty-five infants (11%) were diagnosed with LCC. Infants with a shorter gestation and lower birth weight had a higher incidence of LCC. LCC infants had a significantly lower 1-min Apgar score, significantly higher incidence of severe intraventricular hemorrhage, chronic lung disease, and postnatal periventricular leukomalacia, and significantly longer duration of ventilation use, oxygen use, and hospital stay. Somatic growth at 36 weeks' postmenstrual age was poorer in infants with LCC than without LCC (controls). LCC infants were significantly more likely than controls to have cerebral palsy at 3 years.

Conclusion: LCC is associated with poor neurodevelopmental outcomes. Prevention of LCC can lead to improved neurological prognoses.

PubMed Disclaimer

References

    1. Helbock HJ, Insoft RM, Conte FA. Glucocorticoid-responsive hypotension in extremely low birth weight newborns. Pediatrics. 1993;92 (5:715–717. - PubMed
    1. Fauser A, Pohlandt F, Bartmann P, Gortner L. Rapid increase of blood pressure in extremely low birth weight infants after a single dose of dexamethasone. Eur J Pediatr. 1993;152 (4:354–356. - PubMed
    1. Sasidharan P.Role of corticosteroids in neonatal blood pressure homeostasis Clin Perinatol 199825(3723–740.xi. - PubMed
    1. Gaissmaier RE, Pohlandt F. Single-dose dexamethasone treatment of hypotension in preterm infants. J Pediatr. 1999;134 (6:701–705. - PubMed
    1. Ng PC, Lam CW, Fok TF, Lee CH, Ma KC, Chan IH, et al. Refractory hypotension in preterm infants with adrenocortical insufficiency. Arch Dis Child Fetal Neonatal Ed. 2001;84 (2:F122–F124. - PMC - PubMed

MeSH terms

Substances