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. 2010 Nov;40(11):1311-21.
doi: 10.1007/s10803-010-0992-0.

Prenatal and perinatal risk factors for autism in China

Xin Zhang  1 , Cong-Chao Lv, Jiang Tian, Ru-Juan Miao, Wei Xi, Irva Hertz-Picciotto, Lihong Qi
Affiliations

Prenatal and perinatal risk factors for autism in China

Xin Zhang et al. J Autism Dev Disord. 2010 Nov.

Erratum in

  • J Autism Dev Disord. 2010 Nov;40(11):1322

Abstract

We conducted a case-control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old).

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References

    1. Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Molecular Psychiatry. 2006;11(1):47–55. doi: 10.1038/sj.mp.4001748. - DOI - PubMed
    1. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, et al. Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine. 1995;25(1):63–77. doi: 10.1017/S0033291700028099. - DOI - PubMed
    1. Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The special needs and autism project (SNAP) Lancet. 2006;368(9531):210–215. doi: 10.1016/S0140-6736(06)69041-7. - DOI - PubMed
    1. Bertrand J, Mars A, Boyle C, Bove F, Yeargin-Allsopp M, Decoufle P. Prevalence of autism in a United States population: The Brick Township, New Jersey, investigation. Pediatrics. 2001;108(5):1155–1161. doi: 10.1542/peds.108.5.1155. - DOI - PubMed
    1. Bilder D, Pinborough-Zimmerman J, Miller J, McMahon W. Prenatal, perinatal, and neonatal factors associated with autism spectrum disorders. Pediatrics. 2009;123(5):1293–1300. doi: 10.1542/peds.2008-0927. - DOI - PubMed

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