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. 2010 May 7;12(9):2028-31.
doi: 10.1021/ol1005104.

Enantioselective alpha-amination of 1,3-dicarbonyl compounds using squaramide derivatives as hydrogen bonding catalysts

Hideyuki Konishi  1 , Tin Yiu Lam, Jeremiah P Malerich, Viresh H Rawal
Affiliations

Enantioselective alpha-amination of 1,3-dicarbonyl compounds using squaramide derivatives as hydrogen bonding catalysts

Hideyuki Konishi et al. Org Lett. .

Abstract

Catalytic enantioselective alpha-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.

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Figures

Figure 1
Figure 1
Structures of Catalysts
See this image and copyright information in PMC

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