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Review
. 2010 Apr;24(2):407-22.
doi: 10.1016/j.hoc.2010.02.003.

Hematopoietic stem cell transplantation for MDS

Matthias Bartenstein  1 , H Joachim Deeg
Affiliations
Review

Hematopoietic stem cell transplantation for MDS

Matthias Bartenstein et al. Hematol Oncol Clin North Am. 2010 Apr.

Abstract

Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS). However, as the majority of patients with MDS are in the seventh or eighth decade of life, conventional transplant regimens have been used only infrequently, and only with the development of reduced-intensity conditioning has transplantation been applied more broadly to older patients. Dependent upon disease status at the time of transplantation, 30% to 70% of patients can be expected to be cured of their disease and survive long term. However, posttransplant relapse and graft-versus-host disease (GVHD) remain problems and further investigations are needed.

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