Comment
doi: 10.1038/ncb0410-308.
Abscission accomplished by PtdIns(3)P
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- PMID: 20360746
- DOI: 10.1038/ncb0410-308
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Comment
Abscission accomplished by PtdIns(3)P
Nat Cell Biol.
2010 Apr.
Abstract
Cytokinesis - the final step of mitosis in which the two daughter cells separate - requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.
Comment on
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