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Comment
. 2010 Apr;12(4):308-10.
doi: 10.1038/ncb0410-308.

Abscission accomplished by PtdIns(3)P

Guillaume Montagnac  1 , Philippe Chavrier
Affiliations
Comment

Abscission accomplished by PtdIns(3)P

Guillaume Montagnac et al. Nat Cell Biol. 2010 Apr.

Abstract

Cytokinesis - the final step of mitosis in which the two daughter cells separate - requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.

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References

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