Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 May;222(1-2):70-5.
doi: 10.1016/j.jneuroim.2010.03.003. Epub 2010 Apr 2.

Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis

M Camiña-Tato  1 , M Fernández, C Morcillo-Suárez, A Navarro, E Julià, M C Edo, X Montalban, M Comabella
Affiliations

Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis

M Camiña-Tato et al. J Neuroimmunol. 2010 May.

Abstract

We investigated caspase 8 (CASP8) as a candidate gene for multiple sclerosis (MS) susceptibility. Three SNPs (rs2037815, rs12990906 and rs1035140) were genotyped in 546 MS patients and 547 controls. For SNP rs2037815, GG homozygosity was associated with primary progressive multiple sclerosis (PPMS) when compared with relapse-onset MS and controls. We identified risk (GCA) and protective (ACT) haplotypes associated with PPMS when compared with relapse-onset MS and controls. GG homozygosity for SNP rs2037815 in PPMS patients was associated with a trend towards faster disease progression. These findings point to a role of CASP8 polymorphisms in the MS genetic risk in PPMS patients.

PubMed Disclaimer

Comment in

  • CASP8 in MS.
    Sand PG. Sand PG. J Neuroimmunol. 2011 Jan;230(1-2):192; author reply 193. doi: 10.1016/j.jneuroim.2010.09.018. Epub 2010 Oct 13. J Neuroimmunol. 2011. PMID: 20947178 No abstract available.

Publication types

MeSH terms

LinkOut - more resources