Extraneural sclerosing perineurioma of the buccal mucosa: a case report and clinicopathologic review

Abstract

The perineurioma is an infrequently encountered benign peripheral nerve sheath tumor composed of a clonal proliferation of perineurial cells. Rare cases of perineurioma have been reported in the oral cavity. An extraneural sclerosing perineurioma arising in the buccal mucosa of a 17-year-old male is presented. Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged around vascular channels. The tumor cells reveal positive immunostaining for epithelial membrane antigen (EMA), collagen type IV and vimentin, and negative immunostaining for S-100 protein, consistent with a perineurial origin. To the best of our knowledge, this case represents the first report of an extraneural sclerosing perineurioma involving the oral cavity.

Fig. 1

Low-power view showing a well-circumscribed densely collagenized proliferation of spindle cells exhibiting a vague storiform arrangement. (Hematoxylin and eosin [H&E], original magnification, 20×)

Fig. 2

Hypercellular areas composed of spindle-shaped mesenchymal cells juxtaposed with hypocellular areas (H&E, original magnification, 100×)

Fig. 3

Photomicrographs showing positive immunohistochemical staining in the tumor cell population for: a epithelial membrane antigen (EMA); b vimentin; and c collagen type IV. (Original magnification of each photomicrograph, 200×)