Comparative Study
[Comparative study of resistance to acycloguanosine and acycloguanosine H-phosphonate in herpes simplex virus]
[Article in
Russian]
- PMID: 20364669
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Comparative Study
[Comparative study of resistance to acycloguanosine and acycloguanosine H-phosphonate in herpes simplex virus]
[Article in
Russian]
Vopr Virusol.
2010 Jan-Feb.
Abstract
The ability of acycloguanosine H-phosphate to inhibit the reproduction of herpes simplex virus type 1 (HSV-1) variants, including its acycloguanosine (acyclovir)-resistant ones, was studied. Acycloguanosine H-phosphate-resistant HSV-1 variants were obtained. It was found that these variants were cross-resistant to thymidine kinase-dependent HSV reproduction inhibitors, but preserved sensitivity to Apa-A and phosphonoacetic acid.
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