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. 2007 Fall;1(3):189-94.
doi: 10.4162/nrp.2007.1.3.189. Epub 2007 Sep 30.

The antioxidant and cytotoxic activities of Sonchus oleraceus L. extracts

Jie Yin  1 , Gu-Joong Kwon, Myeong-Hyeon Wang
Affiliations

The antioxidant and cytotoxic activities of Sonchus oleraceus L. extracts

Jie Yin et al. Nutr Res Pract. 2007 Fall.

Abstract

This study investigated in vitro antioxidant activity of Sonchus oleraceus L. by extraction solvent, which were examined by reducing power, hydroxyl radical-scavenging activity(HRSA) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assays. 70% MeOH extract had the greatest reducing power while EtOH extract had the greatest HRSA. The antioxidant activity of S. oleraceus extracts was concentration dependent and its IC(50) values ranged from 47.1 to 210.5 microg/ml and IC(50) of 70% MeOH, boiling water and 70% EtOH extracts were 47.1, 52.7 and 56.5 microg/ml, respectively. 70% MeOH extract of S. oleraceus contained the greatest amount of both phenolic and flavonoid contents. The extracts tested had greater nitrite scavenging effects at lower pH conditions. The cytotoxic activity showed that EtOH extract had the best activity against the growth of stomach cancer cell. These results suggest that S. oleraceus extract could be used as a potential source of natural antioxidants.

Keywords: Antioxidant; Cytotoxic; Nitrite scavenging activity; Phenolic content; Sonchus oleraceus L.

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Figures

Fig. 1
Fig. 1
Effects of different solvents used to produce extracts from S. oleraceus on reducing power. The concentrations of these extracts were the same as 500 µg/ml. Vitamin E at the same concentration of 500 µg/ml was used as the positive control.
Fig. 2
Fig. 2
Effects of different solvents used to produce extracts from S. oleraceus on Hydroxyl radical (·OH) scavenging assay. The concentrations of different solvent extracts were 100 (□), 500 (▨) and 1000 (▪) µg/ml, respectively. Vitamin E and BHT at the concentration of 100 µg /ml were used as the positive control.
Fig. 3
Fig. 3
Nitrite scavenging activity of various extracts from S. oleraceus. The pH of different solvent extracts was 1.2 (□), 4.2 (▨) and 6.0 (▪), respectively.
Fig. 4
Fig. 4
Inhibitory effect of various extracts from S. oleraceus on the growth of NCI-N87 in MTT assay. The concentration of all of the tested extracts was the same as 100 µg/ml. Paclitaxel at the concentration of 100 µg/ml was used as the positive control.
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