Clinical Trial
doi: 10.1016/s0015-0282(16)54374-x.
Prolonged follicle stimulation decreases pregnancy rates after in vitro fertilization
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- PMID: 2037113
- DOI: 10.1016/s0015-0282(16)54374-x
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Clinical Trial
Prolonged follicle stimulation decreases pregnancy rates after in vitro fertilization
Fertil Steril.
1991 Jun.
Free article
Abstract
Ovarian stimulation with a GnRH-a and hMG for IVF treatment offers the potential to extend the period of follicle recruitment and growth free of the restriction imposed by a spontaneous midcycle LH surge. A randomized trial investigating the impact of extending follicle growth by 1 day resulted in a significantly reduced PR, despite an increase in the number of larger follicles (greater than or equal to 17 mm) at the time of hCG. The reason for a reduced PR was not related to the number of ova recovered or embryo quality. This suggests that follicular aging or the duration of estrogen rise may be important.
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