[Molecular mechanisms of mutagenesis caused by apurinic/apyrimidinic DNA sites]

Abstract

The subject of this review are molecular mechanisms and specificity of mutagenesis induced by apurinic/apyrimidinic (AP) sites representing a characteristic group of so called non-coding DNA lesions. The data available suggest that efficiency and specificity of AP sites-induced mutations depend, primarily, on genome structural organization. This is manifested in existence of DNA sequences highly prone to depurination/depyrimidination as well as in the ability of specific DNA regions to adopt potentially mutagenic conformations. The latter leads to mutations as consequence of AP sites' repair. Secondly, the AP sites-induced mutagenesis depends on functional state of genome, on the ability of replicative/repair cell apparatus to carry out some specific forms of mutagenic DNA repair, in particular, to bypass non-coding DNA lesions under conditions of SOS repair.