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Review
. 2010 Aug;67(16):2773-86.
doi: 10.1007/s00018-010-0357-z. Epub 2010 Apr 6.

Dengue virus life cycle: viral and host factors modulating infectivity

Izabela A Rodenhuis-Zybert  1 , Jan Wilschut, Jolanda M Smit
Affiliations
Review

Dengue virus life cycle: viral and host factors modulating infectivity

Izabela A Rodenhuis-Zybert et al. Cell Mol Life Sci. 2010 Aug.

Abstract

Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50-100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.

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Figures

Fig. 1
Fig. 1
Dengue E protein dimer with three defined domains within each monomer: domain I in red, domain II in yellow with fusion loop in green, and domain III in blue (23). The image was prepared using the program PyMol Molecular Graphics System
Fig. 2
Fig. 2
Life cycle of Dengue virus. See text for details. Adapted from H. M. van der Schaar
Fig. 3
Fig. 3
Schematic representation of Dengue virus genome. See text for details
Fig. 4
Fig. 4
Immunopathogenesis of severe dengue—an integrated model
See this image and copyright information in PMC

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