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Randomized Controlled Trial
. 2010 Jul;27(7):357-63.
doi: 10.1007/s10815-010-9412-9. Epub 2010 Apr 6.

Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial

Abbas Aflatoonian  1 , Homa Oskouian, Shahnaz Ahmadi, Leila Oskouian
Affiliations
Randomized Controlled Trial

Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial

Abbas Aflatoonian et al. J Assist Reprod Genet. 2010 Jul.

Retraction in

Abstract

Purpose: Controlled ovarian hyperstimulation has been shown to advance endometrial maturation and adversely affects implantation in ART. It has been reported that there is a better embryo-endometrium synchrony in frozen-thawed embryo transfer cycles than fresh embryo transfer cycles. The objective of this study was to compare ongoing pregnancy rates between fresh ET and FET cycles.

Methods: In an open prospective, controlled study, the patients who were classified as high responders, were randomized to either fresh ET or FET. The embryos in FET group were cryopreserved with vitrification by Cryotop method.

Results: A total of 374 patients were included, 187 of which were randomized to FET and 187 to fresh ET. There were 39% (n = 73) ongoing pregnancy in FET group compared with 27.8% (n = 52) in fresh ET group[odds ratio = 1.66;95% confidence interval = 1.07-2.56; p = 0.02].

Conclusions: FETs can be performed instead of fresh ETs to improve the outcome of ART in highly selected patients.

Trial registration: ClinicalTrials.gov NCT00823121.

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Figures

Fig. 1
Fig. 1
Recruitment follow-up and drop outs over the course of the study
See this image and copyright information in PMC

References

    1. Donaghy M, Lessey BA. Uterine receptivity: alternations associated with benign gynecologic disease. Semin Reprod Med. 2007;25:461–475. doi: 10.1055/s-2007-991044. - DOI - PubMed
    1. Paulson RJ, Sauer MV, Lobo RA. Factors affecting implantation after human in vitro fertilization: a hypothesis. Am J Obstet Gynecol. 1990;163:2020–2023. doi: 10.1016/0002-9378(90)90790-E. - DOI - PubMed
    1. Check JH, Choe JK, Katsoff D, Summers-Chase D, Wilson C. Controlled ovarian hyperstimulation adversely affects implantation following in vitro fertilization-embryo transfer. J Assist Reprod Genet. 1999;16:416–420. doi: 10.1023/A:1020565408018. - DOI - PMC - PubMed
    1. Devroey P, Bourgian C, Macklon N, Fauser B. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab. 2004;15:84–90. doi: 10.1016/j.tem.2004.01.009. - DOI - PubMed
    1. Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, et al. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone-antagonist and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002;78:1025–1029. doi: 10.1016/S0015-0282(02)03323-X. - DOI - PubMed

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