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Multicenter Study
. 2010 Mar;67(3):398-404.
doi: 10.1002/ana.21888.

Pregnancy increases the growth rates of World Health Organization grade II gliomas

Johan Pallud  1 , Emmanuel Mandonnet, Christophe Deroulers, Denys Fontaine, Mathilde Badoual, Laurent Capelle, Frédérique Guillet-May, Philippe Page, Philippe Peruzzi, Emmanuel Jouanneau, Marc Frenay, Stéphanie Cartalat-Carel, Hugues Duffau, Luc Taillandier; Club de Neuro-Oncologie de la Société Française de Neurochirurgie (SFNC); Association des Neuro-Oncologues d'Expression Française (ANOCEF)
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Multicenter Study

Pregnancy increases the growth rates of World Health Organization grade II gliomas

Johan Pallud et al. Ann Neurol. 2010 Mar.

Abstract

Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.

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