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Comment
. 2010 Mar;7(1):83-4; discussion 85-7.
doi: 10.1016/j.plrev.2010.01.007. Epub 2010 Jan 14.

Has innate immunity evolved through different routes?

Nicolò Parrinello  1
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Has innate immunity evolved through different routes?

Nicolò Parrinello. Phys Life Rev. 2010 Mar.

Abstract

Invertebrate self/non-self recognition, defense responses, mating and development share innate immune surveillance and functions challenged by competition and linked to fitness. Independent evolutionary branches of immune responses may use conserved gene traits. On the other hand immunity genes may be conserved due to their role in development. Finally, upregulation of innate immunity genes during ascidian metamorphosis supports the danger hypothesis.

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