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. 1991 Mar;27(3):329-33.
doi: 10.1093/jac/27.3.329.

Reproducibility of the measurement of ciprofloxacin concentration in bronchial mucosa

J Winter  1 , G Sweeney
Affiliations

Reproducibility of the measurement of ciprofloxacin concentration in bronchial mucosa

J Winter et al. J Antimicrob Chemother. 1991 Mar.

Erratum in

  • J Antimicrob Chemother 1991 Sep;28(3):481

Abstract

The reproducibility of ciprofloxacin estimations was investigated in duplicate samples of bronchial mucosa from patients undergoing fibreoptic bronchoscopy. At the time of biopsy, venous blood was collected from each patient. Between 3.5 and 5.0 h after dosing, penetration (%) into the mucosa was 162.13 (S.D. 19.77). The correlation coefficient (Pearson's) between duplicate samples was 0.93. The confidence limits (95%) for a single measurement were +/- 1.47 mg/kg.

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