Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Nov;71(6):691-5.
doi: 10.4103/0250-474X.59556.

Antidiarrhoeal Activity of Leaves of Melastoma malabathricum Linn

J A J Sunilson  1 , K Anandarajagopal, A V A G Kumari, S Mohan
Affiliations

Antidiarrhoeal Activity of Leaves of Melastoma malabathricum Linn

J A J Sunilson et al. Indian J Pharm Sci. 2009 Nov.

Abstract

The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.

Keywords: Antidiarrhoeal activity; Melastoma malabathricum; castrol-induced diarrhea; water extract of the leaf.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chitme HR, Ramesh C, Sadhna K. Study of antidiarrhoeal activity of Calotropis gigantea in experimental animals. J Pharmacol Pharm Sci. 2004;7:70–5. - PubMed
    1. Anonymous Epidemic diarrhoea due to Vibrio cholera. Wkly Epidemic Rec. 1979;16:121.
    1. Sulaiman MR, Somchit MN, Israf DA, Ahmad Z, Moin S. Antinociceptive Effects of Melastoma malabathricum ethanolic extract in mice. Fitoterapia. 2007;75:667–72. - PubMed
    1. Anonymous. Nature cure senduduk. Available from: http://www.Forest [last accessed on 2007 Nov 13]
    1. Anonymous. Database on important medicinal and aromatic plants. Available from: http://www.medicinal /plant.com [last accessed on 2007 Nov 14]

LinkOut - more resources