Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 May;51(3):339-44.
doi: 10.3349/ymj.2010.51.3.339.

Correlation between hyperghrelinemia and carotid artery intima-media thickness in children with Prader-Willi syndrome

Su Jin Kim  1 , Kyung Hoon Paik, Dong-Ik Kim, Yon Ho Choe, Seon Woo Kim, Dong-Kyu Jin
Affiliations

Correlation between hyperghrelinemia and carotid artery intima-media thickness in children with Prader-Willi syndrome

Su Jin Kim et al. Yonsei Med J. 2010 May.

Abstract

Purpose: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability. The objective of the study is to assess the relationship between carotid intima-media thickness (IMT) and atherosclerotic risk factors.

Materials and methods: Twenty-seven PWS children and 24 normal controls were enrolled. Correlations of IMT with atherosclerotic risk factors were assessed.

Results: IMTs in the PWS group did not differ from those in the controls (p = 0.172), although total ghrelin levels were higher in the PWS children (p = 0.003). The multivariate analysis revealed positive correlations between total ghrelin levels ( = 0.489, p = 0.046) and IMT in the PWS group and between body mass index-standard deviation score (BMI-SDS) ( = 0.697, p = 0.005) and IMT in the controls.

Conclusion: Considering the positive correlation of IMT with total ghrelin levels and the high level of ghrelin in PWS children, a further study is warranted to evaluate the role of elevated ghrelin on atherosclerosis for PWS.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Correlation of intima media thickness (IMT) with total ghrelin in the PWS group (A) and BMI-SDS in the controls (B). IMT was significantly positively correlated with total ghrelin in the PWS group (ρ = 0.489, p = 0.046). and BMI-SDS in the controls (ρ = 0.697, p = 0.005). PWS, Prader-Willi syndrome; BMI-SDS, body mass index-standard deviation score.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ishikawa T, Kibe T, Wada Y. Deletion of small nuclear ribonucleoprotein polypeptide N (SNRPN) in Prader-Willi syndrome detected by fluorescence in situ hybridization: two sibs with the typical phenotype without a cytogenetic deletion in chromosome 15q. Am J Med Genet. 1996;62:350–352. - PubMed
    1. MacDonald HR, Wevrick R. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. Hum Mol Genet. 1997;6:1873–1878. - PubMed
    1. Robinson WP, Bottani A, Xie YG, Balakrishman J, Binkert F, Mächler M, et al. Molecular, cytogenetic, and clinical investigations of Prader-Willi syndrome patients. Am J Hum Genet. 1991;49:1219–1234. - PMC - PubMed
    1. Pomara C, D'Errico S, Riezzo I, de Cillis GP, Fineschi V. Sudden cardiac death in a child affected by Prader-Willi syndrome. Int J Legal Med. 2005;119:153–157. - PubMed
    1. Lamb AS, Johnson WM. Premature coronary artery atherosclerosis in a patient with Prader-Willi syndrome. Am J Med Genet. 1987;28:873–880. - PubMed

Publication types