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. 2010 May;51(3):339-44.
doi: 10.3349/ymj.2010.51.3.339.

Correlation between hyperghrelinemia and carotid artery intima-media thickness in children with Prader-Willi syndrome

Su Jin Kim  1 , Kyung Hoon Paik, Dong-Ik Kim, Yon Ho Choe, Seon Woo Kim, Dong-Kyu Jin
Affiliations

Correlation between hyperghrelinemia and carotid artery intima-media thickness in children with Prader-Willi syndrome

Su Jin Kim et al. Yonsei Med J. 2010 May.

Abstract

Purpose: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability. The objective of the study is to assess the relationship between carotid intima-media thickness (IMT) and atherosclerotic risk factors.

Materials and methods: Twenty-seven PWS children and 24 normal controls were enrolled. Correlations of IMT with atherosclerotic risk factors were assessed.

Results: IMTs in the PWS group did not differ from those in the controls (p = 0.172), although total ghrelin levels were higher in the PWS children (p = 0.003). The multivariate analysis revealed positive correlations between total ghrelin levels ( = 0.489, p = 0.046) and IMT in the PWS group and between body mass index-standard deviation score (BMI-SDS) ( = 0.697, p = 0.005) and IMT in the controls.

Conclusion: Considering the positive correlation of IMT with total ghrelin levels and the high level of ghrelin in PWS children, a further study is warranted to evaluate the role of elevated ghrelin on atherosclerosis for PWS.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Correlation of intima media thickness (IMT) with total ghrelin in the PWS group (A) and BMI-SDS in the controls (B). IMT was significantly positively correlated with total ghrelin in the PWS group (ρ = 0.489, p = 0.046). and BMI-SDS in the controls (ρ = 0.697, p = 0.005). PWS, Prader-Willi syndrome; BMI-SDS, body mass index-standard deviation score.
See this image and copyright information in PMC

References

    1. Ishikawa T, Kibe T, Wada Y. Deletion of small nuclear ribonucleoprotein polypeptide N (SNRPN) in Prader-Willi syndrome detected by fluorescence in situ hybridization: two sibs with the typical phenotype without a cytogenetic deletion in chromosome 15q. Am J Med Genet. 1996;62:350–352. - PubMed
    1. MacDonald HR, Wevrick R. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. Hum Mol Genet. 1997;6:1873–1878. - PubMed
    1. Robinson WP, Bottani A, Xie YG, Balakrishman J, Binkert F, Mächler M, et al. Molecular, cytogenetic, and clinical investigations of Prader-Willi syndrome patients. Am J Hum Genet. 1991;49:1219–1234. - PMC - PubMed
    1. Pomara C, D'Errico S, Riezzo I, de Cillis GP, Fineschi V. Sudden cardiac death in a child affected by Prader-Willi syndrome. Int J Legal Med. 2005;119:153–157. - PubMed
    1. Lamb AS, Johnson WM. Premature coronary artery atherosclerosis in a patient with Prader-Willi syndrome. Am J Med Genet. 1987;28:873–880. - PubMed

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