doi: 10.1016/j.bmcl.2010.03.069.
Epub 2010 Mar 21.
Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors
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- PMID: 20378346
- DOI: 10.1016/j.bmcl.2010.03.069
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Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors
Bioorg Med Chem Lett.
.
Abstract
The development and synthesis of potent p38alpha MAP kinase inhibitors containing a 2H-quinolizin-2-one platform is described. Evolution of the 2H-quinolizin-2-one series from an early lead to solving off target activity and pharmacokinetic issues is also discussed.
2010 Elsevier Ltd. All rights reserved.
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