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Case Reports
. 2013 Mar;32 Suppl 1(Suppl 1):S47-9.
doi: 10.1007/s10067-010-1438-y. Epub 2010 Apr 9.

Precore mutant hepatitis B virus-associated fulminant hepatitis during infliximab therapy for rheumatoid arthritis

Hiroko Kuwabara  1 , Akira Fukuda, Yasuhiro Tsuda, Yuro Shibayama
Affiliations
Case Reports

Precore mutant hepatitis B virus-associated fulminant hepatitis during infliximab therapy for rheumatoid arthritis

Hiroko Kuwabara et al. Clin Rheumatol. 2013 Mar.

Abstract

A 73-year-old female, who suffered from rheumatoid arthritis for 10 years, developed precore mutant hepatitis B virus-associated fulminant hepatitis after 1 year of infliximab therapy and subsequent methotrexate withdrawal. We emphasize the importance of preemptive antiviral therapy before starting infliximab administration and withdrawing immunosuppressive drugs.

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Figures

Fig. 1
Fig. 1
Liver histology. a Massive hepatocytic necrosis (H&E stain, 4×). b Predominantly infiltrated CD8 positive lymphocytes (20×). c Amyloid A immunoreactivity of the hepatic artery (10×)
See this image and copyright information in PMC

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References

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