Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Mar;32 Suppl 1(Suppl 1):S47-9.
doi: 10.1007/s10067-010-1438-y. Epub 2010 Apr 9.

Precore mutant hepatitis B virus-associated fulminant hepatitis during infliximab therapy for rheumatoid arthritis

Hiroko Kuwabara  1 , Akira Fukuda, Yasuhiro Tsuda, Yuro Shibayama
Affiliations
Case Reports

Precore mutant hepatitis B virus-associated fulminant hepatitis during infliximab therapy for rheumatoid arthritis

Hiroko Kuwabara et al. Clin Rheumatol. 2013 Mar.

Abstract

A 73-year-old female, who suffered from rheumatoid arthritis for 10 years, developed precore mutant hepatitis B virus-associated fulminant hepatitis after 1 year of infliximab therapy and subsequent methotrexate withdrawal. We emphasize the importance of preemptive antiviral therapy before starting infliximab administration and withdrawing immunosuppressive drugs.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Liver histology. a Massive hepatocytic necrosis (H&E stain, 4×). b Predominantly infiltrated CD8 positive lymphocytes (20×). c Amyloid A immunoreactivity of the hepatic artery (10×)
See this image and copyright information in PMC

References

    1. Furst DE, Keystone EC, Fleischmann R, Mease P, Breedveld FC, Smolen JS, et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2009. Ann Rheum Dis. 2010;69(Suppl 1):i2–i29. doi: 10.1136/ard.2009.123885. - DOI - PubMed
    1. Ostuni P, Botsios C, Punzi L, Sfriso P, Todesco S. Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low dose methotrexate. Ann Rheum Dis. 2003;62:686–687. doi: 10.1136/ard.62.7.686. - DOI - PMC - PubMed
    1. Esteve M, Saro C, Gonzalez-Huix F, Suarez F, Forne M, Viver JM. Chronic hepatitis B reactivation following infliximab therapy in Crohn’s disease patients: need for primary prophylaxis. Gut. 2004;53:1363–1365. doi: 10.1136/gut.2004.040675. - DOI - PMC - PubMed
    1. Millonig G, Kern M, Ludwiczek O, Nachbaur K, Vogel W. Subfulminat hepatitis B after infliximab in Crohn’s disease: need for HBV-screening? World J Gastroenterol. 2006;12:974–976. - PMC - PubMed
    1. Colbert C, Chavarria A, Berkelhammer C. Fulminant hepatic failure in chronic hepatitis B on withdrawal of corticosteroids, azathioprine and infliximab for Crohn’s disease. Inflamm Bowel Dis. 2007;13:1453–1454. doi: 10.1002/ibd.20216. - DOI - PubMed

Publication types

MeSH terms