Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2010 May;45(5):445-50.
doi: 10.1007/s11745-010-3409-0. Epub 2010 Apr 9.

The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients

E S Nakou  1 , T D Filippatos, A P Agouridis, C Kostara, E T Bairaktari, M S Elisaf
Affiliations
Randomized Controlled Trial

The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients

E S Nakou et al. Lipids. 2010 May.

Abstract

We investigated the factors influencing triglycerides (TG) reduction during ezetimibe, alone or combined with orlistat, administration. Eighty-six obese hypercholesterolemic subjects were prescribed a low-fat diet and were randomized to ezetimibe (E group), orlistat (O group), or both (OE group) for 6 months. Plasma TG and apolipoprotein (apo) C-III reduction was significantly greater in the combination group compared with monotherapy. Multivariate analysis showed that in E group apoC-III reduction and baseline TG levels were independently positively correlated, whereas baseline apoC-II levels were negatively correlated, with TG lowering. In OE group apoC-III reduction was the only independent contributor to TG reduction.

PubMed Disclaimer

References

    1. J Clin Invest. 1985 Feb;75(2):384-90 - PubMed
    1. Diabetes Obes Metab. 2008 Jun;10(6):476-83 - PubMed
    1. Curr Opin Lipidol. 2004 Aug;15(4):387-92 - PubMed
    1. Prog Lipid Res. 1991;30(2-3):253-8 - PubMed
    1. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7 - PubMed

Publication types

LinkOut - more resources