Review
doi: 10.1038/cmi.2010.20.
Epub 2010 Apr 12.
Regulatory T cells: immune suppression and beyond
Affiliations
- PMID: 20383175
- PMCID: PMC2868372
- DOI: 10.1038/cmi.2010.20
Item in Clipboard
Review
Regulatory T cells: immune suppression and beyond
Cell Mol Immunol.
2010 May.
Abstract
Foxp3-expressing regulatory T cells (Tregs) were originally identified as critical in maintaining self-tolerance and immune homeostasis. The immunosuppressive functions of Tregs are widely acknowledged and have been extensively studied. Recent studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory response. This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation.
Similar articles
-
Emerging Functions of Regulatory T Cells in Tissue Homeostasis.Front Immunol. 2018 Apr 25;9:883. doi: 10.3389/fimmu.2018.00883. eCollection 2018. Front Immunol. 2018. PMID: 29887862 Free PMC article. Review.
-
Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions.Semin Immunol. 2011 Dec;23(6):424-30. doi: 10.1016/j.smim.2011.10.002. Epub 2011 Nov 3. Semin Immunol. 2011. PMID: 22055883 Review.
-
A wave of Foxp3+ regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance.Cell Mol Immunol. 2020 May;17(5):507-518. doi: 10.1038/s41423-019-0246-9. Epub 2019 Jun 6. Cell Mol Immunol. 2020. PMID: 31171863 Free PMC article.
-
Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression.J Autoimmun. 2014 Dec;55:51-62. doi: 10.1016/j.jaut.2014.05.007. Epub 2014 Jun 14. J Autoimmun. 2014. PMID: 24934597 Free PMC article.
-
Recent advances in regulatory immune cells: exploring the world beyond Tregs.Front Immunol. 2025 May 16;16:1530301. doi: 10.3389/fimmu.2025.1530301. eCollection 2025. Front Immunol. 2025. PMID: 40453084 Free PMC article. Review.
Cited by
-
Lower omental t-regulatory cell count is associated with higher fasting glucose and lower β-cell function in adults with obesity.Obesity (Silver Spring). 2016 Jun;24(6):1274-82. doi: 10.1002/oby.21507. Epub 2016 May 2. Obesity (Silver Spring). 2016. PMID: 27133873 Free PMC article.
-
Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.Retrovirology. 2016 Apr 14;13:24. doi: 10.1186/s12977-016-0258-9. Retrovirology. 2016. PMID: 27076190 Free PMC article. Review.
-
Percentage of Peripheral CD19+CD24hiCD38hi Regulatory B Cells in Neonatal Sepsis Patients and Its Functional Implication.Med Sci Monit. 2016 Jul 7;22:2374-8. doi: 10.12659/msm.895421. Med Sci Monit. 2016. PMID: 27389933 Free PMC article.
-
Strategies of mucosal immunotherapy for allergic diseases.Cell Mol Immunol. 2011 Nov;8(6):453-61. doi: 10.1038/cmi.2011.17. Epub 2011 Jun 13. Cell Mol Immunol. 2011. PMID: 21666705 Free PMC article. Review.
-
Tailoring glucocorticoids in patients with severe COVID-19: a narrative review.Ann Transl Med. 2021 Aug;9(15):1261. doi: 10.21037/atm-21-1783. Ann Transl Med. 2021. PMID: 34532398 Free PMC article. Review.
References
-
- Gershon RK. A disquisition on suppressor T cells. Transplant Rev. 1975;26:170–185. - PubMed
-
- Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151–1164. - PubMed
-
- Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531–562. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
