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Review
. 2010 Feb;4(1):27-36.
doi: 10.2217/bmm.09.89.

Biomarkers of oxidative damage and inflammation in Alzheimer's disease

Douglas Galasko  1 , Thomas J Montine
Affiliations
Review

Biomarkers of oxidative damage and inflammation in Alzheimer's disease

Douglas Galasko et al. Biomark Med. 2010 Feb.

Abstract

Oxidative damage and inflammation are important features of the brain pathology of Alzheimer's disease (AD). Oxidative damage can be found in membranes (lipid peroxidation), proteins (nitrosylation and other post-translational changes) and nucleic acids. Inflammatory changes include activation of microglia and astrocytes, with increased levels of proinflammatory cytokines. Not all of these changes are specific to AD, and occur in other neurodegenerative disorders. Both oxidative stress and inflammation are potential therapeutic targets in AD, and biomarkers could help to identify and monitor key pathways in patients with AD. This article summarizes progress in developing cerebrospinal fluid biomarkers related to oxidative stress and inflammation, problems and pitfalls related to systemic (blood- or urine-based) biomarkers in this area, and future research directions and applications.

Keywords: Alzheimer’s disease; F2-isoprostanes; biomarker; cytokines; oxidative stress.

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References

Bibliography

    1. Markesbery WR. Oxidative stress hypothesis in Alzheimer’s disease. Free Radic. Biol. Med. 1997;23:134–147. - PubMed
    1. Perry G, Nunomura A, Hirai K, et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? Free Radic. Biol. Med. 2002;33:1475–1479. - PubMed
    1. Golden TR, Hinerfeld DA, Melov S. Oxidative stress and aging: beyond correlation. Aging Cell. 2002;1:117–123. - PubMed
    1. Keller JN, Schmitt FA, Scheff SW, et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology. 2005;64:1152–1156. - PubMed
    1. Schwab C, McGeer PL. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. J. Alzheimers Dis. 2008;13:359–369. - PubMed

Website

    1. Alzheimer’s disease Neuroimaging Initative (ADNI) www.adni.org.

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