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. 2010 May 28;73(5):992-4.
doi: 10.1021/np100078s.

Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera

Joshua Parks  1 , Thinley Gyeltshen, Vilailak Prachyawarakorn, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
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Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera

Joshua Parks et al. J Nat Prod. .

Abstract

Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia.

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