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Comparative Study
. 1978 Feb;53(1):21-7.
doi: 10.1016/0165-1161(78)90376-x.

EMS-induced dominant lethal dose response curve in DBA/1J male mice

J Favor, J W Crenshaw
Comparative Study

EMS-induced dominant lethal dose response curve in DBA/1J male mice

J Favor et al. Mutat Res. 1978 Feb.

Abstract

An ethyl methanesulfonate (EMS) induced dominant lethal dose response experiment was conducted in strain DBA/1J male mice. Two methods of scoring for dominant lethals, the classic method (dissecting females at mid-pregnancy) and an alternative method (inspection of uterine scars after litters were weaned) were compared. Results indicate that strain DBA/1J has a similar sensitivity to EMS-induced dominant lethals as has been previously reported for other mouse genotypes. Of the two methods used to score dominant lethals, the classic method is more sensitive.

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