King of the castle: competition between repressors and activators on the Mcm1 platform
- PMID: 20385083
- DOI: 10.1016/j.molcel.2010.03.011
King of the castle: competition between repressors and activators on the Mcm1 platform
Abstract
Darieva and coworkers (Darieva et al., 2010) have shown that the repressor Yox1 and the activator Fkh2-Ndd1 associate with opposite sides of the dimeric Mcm1 transcription factor but nevertheless compete for binding; the outcome determines expression of late mitotic genes in yeast.
2010 Elsevier Inc. All rights reserved.
Comment on
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A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression.Mol Cell. 2010 Apr 9;38(1):29-40. doi: 10.1016/j.molcel.2010.02.030. Mol Cell. 2010. PMID: 20385087 Free PMC article.
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