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. 2011 Jan;54 Suppl 1(Suppl 1):S76-82.
doi: 10.1016/j.neuroimage.2010.04.008. Epub 2010 Apr 10.

Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms

Elaine R Peskind  1 , Eric C Petrie, Donna J Cross, Kathleen Pagulayan, Kathleen McCraw, David Hoff, Kim Hart, Chang-En Yu, Murray A Raskind, David G Cook, Satoshi Minoshima
Affiliations

Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms

Elaine R Peskind et al. Neuroimage. 2011 Jan.

Abstract

Disagreement exists regarding the extent to which persistent post-concussive symptoms (PCS) reported by Iraq combat Veterans with repeated episodes of mild traumatic brain injury (mTBI) from explosive blasts represent structural or functional brain damage or an epiphenomenon of comorbid depression or posttraumatic stress disorder (PTSD). Objective assessment of brain function in this population may clarify the issue. To this end, twelve Iraq war Veterans (32.0 ± 8.5 [mean ± standard deviation (SD)] years of age) reporting one or more blast exposures meeting American Congress of Rehabilitation Medicine criteria for mTBI and persistent PCS and 12 cognitively normal community volunteers (53.0 ± 4.6 years of age) without history of head trauma underwent brain fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological assessments and completed PCS and psychiatric symptom rating scales. Compared to controls, Veterans with mTBI (with or without PTSD) exhibited decreased cerebral metabolic rate of glucose in the cerebellum, vermis, pons, and medial temporal lobe. They also exhibited subtle impairments in verbal fluency, cognitive processing speed, attention, and working memory, similar to those reported in the literature for patients with cerebellar lesions. These FDG-PET imaging findings suggest that regional brain hypometabolism may constitute a neurobiological substrate for chronic PCS in Iraq combat Veterans with repetitive blast-trauma mTBI. Given the potential public health implications of these findings, further investigation of brain function in these Veterans appears warranted.

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Figures

Figure 1
Figure 1
Magnetic resonance imaging brain templates (top row) and voxel-wise Z-score maps for each mTBI Veteran participant (S001-S012, lower rows) showing patterns of hypometabolism relative to community volunteer control group (n=12). Views are Right Lateral (RT LAT), Left Lateral (LT LAT), Right Medial (RT MED), Left Medial (LT MED), Superior (SUP), and Inferior (INF). Vertical bar shows image color vs. Z-score scale.
Figure 2
Figure 2
Magnetic Resonance Imaging brain template (top row) and Z-score map of cerebral glucose metabolism difference between mTBI Veteran group (n=12) and community volunteer control group (n=12) (bottom row). Views and vertical bar are the same as in Figure 1.
See this image and copyright information in PMC

References

    1. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM. The development of a Clinician-Administered PTSD Scale. J Trauma Stress. 1995;8:75–90. - PubMed
    1. Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry. 1997;54:246–254. - PubMed
    1. Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Arch Intern Med. 1998;158:1789–1795. - PubMed
    1. Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213. - PubMed
    1. Cicerone K, Kalmar K. Persistent postconcussion syndrome: the structure of subjective complaints after mild traumatic brain injury. J Head Trauma Rehabil. 1995;10:1–17.

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