Prostate cancer: beta control your hormones
- PMID: 20385354
- DOI: 10.1016/j.ccr.2010.03.013
Prostate cancer: beta control your hormones
Abstract
Differentiation status influences the prognosis for localized prostate cancer. In this issue of Cancer Cell, Mak and coworkers describe a signaling pathway involving estrogen receptor beta (ERbeta) that governs whether prostate carcinoma cells maintain an epithelial phenotype or undergo epithelial-mesenchymal transition, suggesting that ERbeta would have prognostic or therapeutic value.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.Cancer Cell. 2010 Apr 13;17(4):319-32. doi: 10.1016/j.ccr.2010.02.030. Cancer Cell. 2010. PMID: 20385358 Free PMC article.
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