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Comment
. 2010 Apr 13;107(15):6557-8.
doi: 10.1073/pnas.1002555107. Epub 2010 Apr 12.

Linking type 2 diabetes and Alzheimer's disease

Weiping Han  1 , Cai Li
Affiliations
Comment

Linking type 2 diabetes and Alzheimer's disease

Weiping Han et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
The underlying links between AD and T2D. (A) Insulin resistance as a mechanistic link between AD and T2D. Insulin resistance in peripheral tissues and organs, when coupled with relative insulin deficiency, causes T2D. On the other hand, central insulin resistance, together with reduced brain insulin levels that might have resulted from T2D, leads to accumulation of β-amyloid and, consequently, AD. (B) Inflammation as a mechanistic link between AD and T2D. Through its influence on islet function and peripheral insulin sensitivity, inflammation accelerates the development of T2D. Cerebrovascular and central inflammation, along with increased accumulation of β-amyloid, disrupts normal synaptic function, a starting point of AD pathological progression.
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