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. 2010 Apr;67(4):428-33.
doi: 10.1001/archneurol.2010.38.

Reduced lean mass in early Alzheimer disease and its association with brain atrophy

Jeffrey M Burns  1 , David K Johnson, Amber Watts, Russell H Swerdlow, William M Brooks
Affiliations

Reduced lean mass in early Alzheimer disease and its association with brain atrophy

Jeffrey M Burns et al. Arch Neurol. 2010 Apr.

Abstract

Objective: To examine body composition in individuals with early AD and without dementia and its relation to cognition and brain volume.

Design: Cross-sectional case-control study.

Participants: Individuals without dementia (Clinical Dementia Rating, 0; n = 70) and with early-stage AD (Clinical Dementia Rating, 0.5 or 1; n = 70) in the Alzheimer and Memory Program at the University of Kansas School of Medicine.

Main outcome measures: Participants were evaluated with brain magnetic resonance imaging (MRI), neuropsychological testing, and dual-energy x-ray absorptiometry to determine whole-body fat and lean masses. Body mass index was calculated as weight in kilograms divided by height in meters squared.

Results: Lean mass was reduced in persons with early AD compared with controls without dementia (F = 7.73; P = .006) after controlling for sex. Whole-brain volume (beta = .20; P < .001), white matter volume (beta = .19; P < .001), and global cognitive performance (beta = .12; P = .007) were associated with lean mass (dependent variable) when controlling for age and sex. The total body fat and percentage of body fat values were not different across groups or related to cognition and brain volume.

Conclusion: Loss of lean mass is accelerated in AD and is associated with brain atrophy and cognitive performance, perhaps as a direct or indirect consequence of AD pathophysiology or through shared mechanisms common to both AD and sarcopenia.

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Figures

Figure 1
Figure 1. Relationship between Lean Mass and Whole Brain Volume
Whole brain volume is positively associated (beta=0.20, p<0.001) with lean mass in early AD and nondemented controls. Whole brain volume is normalized to account for differences in head size and provide an estimate of brain atrophy. For illustrative purposes in the figure, lean mass was adjusted for sex and age and presented in standardized units [Z]. This positive association was not different across AD and nondemented groups and was independent of age, sex, dementia severity, inflammation, insulin, and glucose measures.
See this image and copyright information in PMC

References

    1. White H, Pieper C, Schmader K. The association of weight change in Alzheimer’s Disease with severity of disease and mortality: A longitudinal analysis. Journal of the American Geriatrics Society. 1998;46(10):1223–1227. - PubMed
    1. Johnson DK, Wilkins CH, Morris JC. Accelerated Weight Loss May Precede Diagnosis in Alzheimer Disease. Arch Neurol. 2006 September 1;63(9):1312–1317. - PubMed
    1. Knopman DS, Edland SD, Cha RH, Petersen RC, Rocca WA. Incident dementia in women is preceded by weight loss by at least a decade. 2007;69:739–746. - PubMed
    1. BarrettConnor E, Edelstein SL, CoreyBloom J, Wiederholt WC. Weight loss precedes dementia in community-dwelling older adults. Journal of the American Geriatrics Society. 1996;44(10):1147–1152. - PubMed
    1. Cronk BB, Johnson DK, Burns JM Initiative AsDN. Body Mass Index and Cognitive Decline in Mild Cognitive Impairment. Alzheimer Dis Assoc Disord. 2009 In Press. - PMC - PubMed

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