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. 2010 Jun;117(6):681-7.
doi: 10.1007/s00702-010-0400-0. Epub 2010 Apr 13.

On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079

Daniel Marcellino  1 , Diana Suárez-Boomgaard, María Dolores Sánchez-Reina, José A Aguirre, Takashi Yoshitake, Shimako Yoshitake, Beth Hagman, Jan Kehr, Luigi F Agnati, Kjell Fuxe, Alicia Rivera
Affiliations

On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079

Daniel Marcellino et al. J Neural Transm (Vienna). 2010 Jun.

Abstract

The role of the ATP-gated receptor, P2X(7), has been evaluated in the unilateral 6-OHDA rat model of Parkinson's disease using the P2X(7) competitive antagonist A-438079. Nigral P2X(7) immunoreactivity was mainly located in microglia but also in astroglia. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. However, this was not associated with a reduction of DA cell loss. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease and warrants further future investigation.

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