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. 2010 Apr 27;102(9):1422-7.
doi: 10.1038/sj.bjc.6605658. Epub 2010 Apr 13.

Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies

Y Bao  1 , K Ng, B M Wolpin, D S Michaud, E Giovannucci, C S Fuchs
Affiliations

Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies

Y Bao et al. Br J Cancer. .

Abstract

Background: Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results.

Methods: We prospectively followed 118 597 participants in the Nurses' Health Study and Health Professionals Follow-up Study from 1986 to 2006. We calculated a 25-hydroxyvitamin D (25(OH)D) score from known predictors of vitamin D status for each individual and then examined the predicted 25(OH)D levels in relation to pancreatic cancer risk. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models adjusted for age, sex, race, height, smoking, and diabetes. We then further adjusted for body mass index (BMI) and physical activity in a sensitivity analysis.

Results: During 20 years of follow-up, we identified 575 incident pancreatic cancer cases. Higher 25(OH)D score was associated with a significant reduction in pancreatic cancer risk; compared with the lowest quintile, participants in the highest quintile of 25(OH)D score had an adjusted RR of 0.65 (95% CI=0.50-0.86; P(trend)=0.001). Results were similar when we further adjusted for BMI and physical activity.

Conclusions: Higher 25(OH)D score was associated with a lower risk of pancreatic cancer in these two prospective cohort studies.

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