Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1991:39:291-320.
doi: 10.1016/s0065-3527(08)60798-8.

Pathogenesis of Theiler's murine encephalomyelitis virus

M Yamada  1 , A Zurbriggen, R S Fujinami
Affiliations
Review

Pathogenesis of Theiler's murine encephalomyelitis virus

M Yamada et al. Adv Virus Res. 1991.

Abstract

Theiler's murine encephalomyelitis virus belongs to the family of picornaviridae. Picornaviruses are small ( “pico”), phylogenetically related RNA viruses. Based on different biochemical and biophysical characteristics picornaviruses are subdivided into four groups: enteroaphthovirus (foot-and-mouth disease virus), cardiovirus [encephalomyocarditis virus (EMCV), Mengo virus], and rhinovirus (human rhinovirus). Theiler's murine encephalomyelitis virus was originally classified among the picornaviridae as an enterovirus because of its biological similarities with poliovirus. Further comparison of the complete genome of TMEV BeAn 8386 strain identifies remarkable similarities at the level of nucleotides and predicted amino acids between BeAn and the cardioviruses EMCV and Mengo virus. Theiler's murine encephalomyelitis virus is a single-stranded nonenveloped RNA virus. The viral RNA is of positive sense, having the same polarity as mRNA. Viral mRNA lacks the cap structure found at the 5’ end of almost all eukaryotic mRNAs.

PubMed Disclaimer

References

    1. Acharaya R., Fry E., Stuart D., Fox G., Rowlands D., Brown F. The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution. Nature (London) 1989;337:709–716. - PubMed
    1. Aubert C., Chamorro M., Brahic M. Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease. Microb. Pathog. 1987;3:319–326. - PubMed
    1. Barbano R.L., Dal Canto M.C. Serum and cells from Theiler's virus-infected mice fail to injure myelinating cultures or to produce in vivo transfer of disease. The pathogenesis of Theiler's virus-induced demyelination appears to differ from that of EAE. J. Neurol. Sci. 1984;66:283–293. - PubMed
    1. Blakemore W.F., Welsh C.J.R., Tonks P., Nash A.A. Observations on demyelinating lesions induced by Theiler's virus in CBA mice. Acta Neuropathol. 1988;76:581–589. - PubMed
    1. Brahic M., Stroop W.G., Baringer J.R. Theiler's virus persists in glial cells during demyelinating disease. Cell. 1981;26:123–128. - PubMed

Publication types

MeSH terms

LinkOut - more resources