Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Apr:42 Suppl 1:S3-36.
doi: 10.1055/s-0029-1240928. Epub 2010 Apr 13.

A European evidence-based guideline for the prevention of type 2 diabetes

B Paulweber  1 , P Valensi, J Lindström, N M Lalic, C J Greaves, M McKee, K Kissimova-Skarbek, S Liatis, E Cosson, J Szendroedi, K E Sheppard, K Charlesworth, A-M Felton, M Hall, A Rissanen, J Tuomilehto, P E Schwarz, M Roden, M Paulweber, A Stadlmayr, L Kedenko, N Katsilambros, K Makrilakis, Z Kamenov, P Evans, A Gilis-Januszewska, K Lalic, A Jotic, P Djordevic, V Dimitrijevic-Sreckovic, U Hühmer, B Kulzer, S Puhl, Y H Lee-Barkey, A AlKerwi, C Abraham, W Hardeman, T Acosta, M Adler, A AlKerwi, N Barengo, R Barengo, J M Boavida, K Charlesworth, V Christov, B Claussen, X Cos, E Cosson, S Deceukelier, V Dimitrijevic-Sreckovic, P Djordjevic, P Evans, A-M Felton, M Fischer, R Gabriel-Sanchez, A Gilis-Januszewska, M Goldfracht, J L Gomez, C J Greaves, M Hall, U Handke, H Hauner, J Herbst, N Hermanns, L Herrebrugh, C Huber, U Hühmer, J Huttunen, A Jotic, Z Kamenov, S Karadeniz, N Katsilambros, M Khalangot, K Kissimova-Skarbek, D Köhler, V Kopp, P Kronsbein, B Kulzer, D Kyne-Grzebalski, K Lalic, N Lalic, R Landgraf, Y H Lee-Barkey, S Liatis, J Lindström, K Makrilakis, C McIntosh, M McKee, A C Mesquita, D Misina, F Muylle, A Neumann, A C Paiva, P Pajunen, B Paulweber, M Peltonen, L Perrenoud, A Pfeiffer, A Pölönen, S Puhl, F Raposo, T Reinehr, A Rissanen, C Robinson, M Roden, U Rothe, T Saaristo, J Scholl, P E Schwarz, K E Sheppard, S Spiers, T Stemper, B Stratmann, J Szendroedi, Z Szybinski, T Tankova, V Telle-Hjellset, G Terry, D Tolks, F Toti, J Tuomilehto, A Undeutsch, C Valadas, P Valensi, D Velickiene, P Vermunt, R Weiss, J Wens, T Yilmaz
Affiliations
Free article

A European evidence-based guideline for the prevention of type 2 diabetes

B Paulweber et al. Horm Metab Res. 2010 Apr.
Free article

Abstract

Background: The prevalence and socioeconomic burden of type 2 diabetes (T2DM) and associated co-morbidities are rising worldwide.

Aims: This guideline provides evidence-based recommendations for preventing T2DM.

Methods: A European multidisciplinary consortium systematically reviewed the evidence on the effectiveness of screening and interventions for T2DM prevention using SIGN criteria.

Results: Obesity and sedentary lifestyle are the main modifiable risk factors. Age and ethnicity are non-modifiable risk factors. Case-finding should follow a step-wise procedure using risk questionnaires and oral glucose tolerance testing. Persons with impaired glucose tolerance and/or fasting glucose are at high-risk and should be prioritized for intensive intervention. Interventions supporting lifestyle changes delay the onset of T2DM in high-risk adults (number-needed-to-treat: 6.4 over 1.8-4.6 years). These should be supported by inter-sectoral strategies that create health promoting environments. Sustained body weight reduction by >or= 5 % lowers risk. Currently metformin, acarbose and orlistat can be considered as second-line prevention options. The population approach should use organized measures to raise awareness and change lifestyle with specific approaches for adolescents, minorities and disadvantaged people. Interventions promoting lifestyle changes are more effective if they target both diet and physical activity, mobilize social support, involve the planned use of established behaviour change techniques, and provide frequent contacts. Cost-effectiveness analysis should take a societal perspective.

Conclusions: Prevention using lifestyle modifications in high-risk individuals is cost-effective and should be embedded in evaluated models of care. Effective prevention plans are predicated upon sustained government initiatives comprising advocacy, community support, fiscal and legislative changes, private sector engagement and continuous media communication.

PubMed Disclaimer