doi: 10.1016/j.cub.2010.02.018.
Thymocyte selection: chemokine signaling is not only about the destination
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- PMID: 20392421
- DOI: 10.1016/j.cub.2010.02.018
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Thymocyte selection: chemokine signaling is not only about the destination
Curr Biol.
.
Free article
Abstract
The development and function of lymphocytes depend upon their precise migration in response to chemoattractant cytokines, or chemokines. Two recent reports suggest that, during thymic beta-selection, the binding of the chemokine CXCL12 to the receptor CXCR4 on thymocytes provides not only directional but also developmental cues.
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