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. 2010 Apr 13;20(7):R316-8.
doi: 10.1016/j.cub.2010.02.018.

Thymocyte selection: chemokine signaling is not only about the destination

Michael Gleimer  1 , Harald von Boehmer
Affiliations
Free article

Thymocyte selection: chemokine signaling is not only about the destination

Michael Gleimer et al. Curr Biol. .
Free article

Abstract

The development and function of lymphocytes depend upon their precise migration in response to chemoattractant cytokines, or chemokines. Two recent reports suggest that, during thymic beta-selection, the binding of the chemokine CXCL12 to the receptor CXCR4 on thymocytes provides not only directional but also developmental cues.

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