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. 2010 Jun;125(6):1389-90.
doi: 10.1016/j.jaci.2010.01.047. Epub 2010 Apr 14.

Invasive fungal disease in autosomal-dominant hyper-IgE syndrome

Donald C Vinh, Janyce A Sugui, Amy P Hsu, Alexandra F Freeman, Steven M Holland

Invasive fungal disease in autosomal-dominant hyper-IgE syndrome

Donald C Vinh et al. J Allergy Clin Immunol. 2010 Jun.

Abstract

We demonstrate that autosomal-dominant STAT3-deficient hyper-IgE syndrome confers late-onset susceptibility to molds, especially Aspergillus, despite preserved myeloid functions, in association with previous parenchymal lung damage (bronchiectasis/pneumatoceles). This suggests a critical role for non-hematopoietic processes in innate antifungal immunity in AD-HIES.

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Conflict of interest statement

Potential conflicts of interest: none to declare

Figures

Figure 1
Figure 1
CT of invasive fungal pneumonia in AD-HIES.
Figure 2
Figure 2
Growth inhibition of A. fumigatus hyphae by neutrophils from AD-HIES patients compared to normal donors and CGD patients.
See this image and copyright information in PMC

References

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