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Comment
. 2010 Apr 20;107(16):7117-8.
doi: 10.1073/pnas.1002656107. Epub 2010 Apr 14.

Alternative fuel--another role for p53 in the regulation of metabolism

Karen H Vousden  1
Affiliations
Comment

Alternative fuel--another role for p53 in the regulation of metabolism

Karen H Vousden. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
p53 at the hub of a network of pathways that regulate metabolism and oxidative stress. Many p53-inducible proteins that function in these responses have now been described; for clarity, only some examples have been shown here.
See this image and copyright information in PMC

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References

    1. Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y. Tumour suppression by p53: the importance of apoptosis and cellular senescence. J Pathol. 2009;219:3–15. - PubMed
    1. Vousden KH, Prives C. Blinded by the light: The growing complexity of p53. Cell. 2009;137:413–431. - PubMed
    1. Hu A, et al. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA. 2010;107:7455–7460. - PMC - PubMed
    1. Suzuki S, et al. Phosphate activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci USA. 2010;107:7461–7466. - PMC - PubMed
    1. Gottlieb E, Vousden KH. p53 regulation of metabolic pathways. Cold Spring Harbor Pespect Biol. 2010 10.1101/cshperspec.a001040. - DOI - PMC - PubMed

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