Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 May;30(3):347-57.
doi: 10.1007/s10875-010-9392-7.

Small RNA regulators of T cell-mediated autoimmunity

Lukas T Jeker  1 , Jeffrey A Bluestone
Affiliations
Free article
Review

Small RNA regulators of T cell-mediated autoimmunity

Lukas T Jeker et al. J Clin Immunol. 2010 May.
Free article

Erratum in

  • J Clin Immunol. 2010 Jul;30(4):621

Abstract

Background: MicroRNAs (miRNAs) are short singlestranded RNA molecules that regulate gene expression post-transcriptionally. Several hundred miRNAs exist in the mammalian genome and regulate developmental processes, cell cycle, and survival.

Methods: In this review,we highlight generalmodes of miRNA function and relate them to how such regulation can be beneficial for immune homeostasis and the prevention of autoimmune diseases.We highlight examples of experimentally verified miRNA function and their target genes in the immune system and place them in context of concepts relevant to an understanding of autoimmune pathogenesis. Where available, we refer to clinical correlations. Finally, we speculate how emerging knowledge about miRNA function in the immune system might be used diagnostically and therapeutically.

PubMed Disclaimer

Similar articles

  • Cytokine Targeting by miRNAs in Autoimmune Diseases.
    Salvi V, Gianello V, Tiberio L, Sozzani S, Bosisio D. Salvi V, et al. Front Immunol. 2019 Jan 29;10:15. doi: 10.3389/fimmu.2019.00015. eCollection 2019. Front Immunol. 2019. PMID: 30761124 Free PMC article. Review.
  • Regulatory roles of micro-RNAs in T cell autoimmunity.
    Esmailzadeh S, Mansoori B, Mohammadi A, Baradaran B. Esmailzadeh S, et al. Immunol Invest. 2017 Nov;46(8):864-879. doi: 10.1080/08820139.2017.1373901. Immunol Invest. 2017. PMID: 29058542 Review.
  • MicroRNAs and their emerging roles in immunology.
    Pauley KM, Chan EK. Pauley KM, et al. Ann N Y Acad Sci. 2008 Nov;1143:226-39. doi: 10.1196/annals.1443.009. Ann N Y Acad Sci. 2008. PMID: 19076353 Review.
  • Role of microRNA-155 in autoimmunity.
    Leng RX, Pan HF, Qin WZ, Chen GM, Ye DQ. Leng RX, et al. Cytokine Growth Factor Rev. 2011 Jun;22(3):141-7. doi: 10.1016/j.cytogfr.2011.05.002. Epub 2011 Jun 23. Cytokine Growth Factor Rev. 2011. PMID: 21703910 Review.
  • The role of miRNA in inflammation and autoimmunity.
    Singh RP, Massachi I, Manickavel S, Singh S, Rao NP, Hasan S, Mc Curdy DK, Sharma S, Wong D, Hahn BH, Rehimi H. Singh RP, et al. Autoimmun Rev. 2013 Oct;12(12):1160-5. doi: 10.1016/j.autrev.2013.07.003. Epub 2013 Jul 14. Autoimmun Rev. 2013. PMID: 23860189 Review.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 2007 Feb 15;445(7129):766-70 - PubMed
    1. Immunity. 2009 May;30(5):646-55 - PubMed
    1. J Autoimmun. 2009 May-Jun;32(3-4):189-94 - PubMed
    1. Mol Cell. 2008 May 23;30(4):460-71 - PubMed
    1. Nat Immunol. 2009 Jul;10(7):689-95 - PubMed

Publication types

MeSH terms

LinkOut - more resources