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Randomized Controlled Trial
. 2010 Apr;33(4):222-7.
doi: 10.1002/clc.20724.

Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease

Jia Li  1 , Yan-Ming Sun, Lan-Feng Wang, Zhu-Qin Li, Wei Pan, Hong-Yan Cao
Affiliations
Randomized Controlled Trial

Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease

Jia Li et al. Clin Cardiol. 2010 Apr.

Abstract

Background: HMG-CoA reductase inhibitors (statins) have antiatherogenic effects beyond their cholesterol-lowing effect. Whether atorvastatin has a stronger antioxidant effect than other statins is uncertain.

Hypothesis: To determine the effects of simvastatin and atorvastatin on markers of oxidative stress in patients with coronary heart disease (CHD).

Methods: This study was comprised of 164 patients with CHD and a control population of 122 healthy subjects. The patients with CHD were divided into 2 groups and treated with either simvastatin 20 mg/day or atorvastatin 10 mg/day. The markers of oxidative stress were measured before and after 12 weeks of treatment.

Results: The effects of atorvastatin on reducing oxidative stress were significantly greater compared with those of simvastatin (P < 0.05). The changes in the markers of oxidative stress did not correlate with the changes in the plasma lipid profile (P > 0.05).

Conclusions: This study suggests that atorvastatin reduces oxidative stress more effectively than simvastatin.

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