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. 1991 May 15;276 ( Pt 1)(Pt 1):183-7.
doi: 10.1042/bj2760183.

Expression of type X collagen is transiently stimulated in redifferentiating chondrocytes pretreated with retinoic acid

M Sanchez  1 , E Gionti, G Pontarelli, A Arcella, F De Lorenzo
Affiliations

Expression of type X collagen is transiently stimulated in redifferentiating chondrocytes pretreated with retinoic acid

M Sanchez et al. Biochem J. .

Abstract

Growth of quail chondrocytes in the presence of retinoic acid (RA) results in the suppression of the differentiated phenotype. RA-treated chondrocytes recover their differentiated phenotype if they are cultured for an additional 15 days in the absence of RA. A few days after removal from RA, treated chondrocytes acquire the polygonal morphology characteristic of chondrocytes growing as attached cells; they also gradually resume collagen II expression and synthesize cultures. The levels of collagen X mRNA decrease during the second week of culture in the absence of RA. Finally, at the end of 15 days, the absolute levels of collagen II and collagen X mRNAs are very similar in control and recovering chondrocytes.

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References

    1. J Cell Biol. 1984 Jul;99(1 Pt 1):208-16 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 May;81(10):3014-8 - PubMed
    1. Dev Biol. 1985 Feb;107(2):373-81 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 May;82(9):2756-60 - PubMed
    1. Nucleic Acids Res. 1985 Mar 11;13(5):1431-42 - PubMed

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