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. 1991 May 15;276 ( Pt 1)(Pt 1):265-8.
doi: 10.1042/bj2760265.

How to draw kinetic barrier diagrams for enzyme-catalysed reactions

J Südi  1
Affiliations

How to draw kinetic barrier diagrams for enzyme-catalysed reactions

J Südi. Biochem J. .

Abstract

A modified way to construct kinetic barrier diagrams is presented. Although the diagram superficially resembles a free-energy profile, it is independent of any conception derived from transition-state theory. Some simple calculations referring to the lactate dehydrogenase turnover reaction at equilibrium demonstrate self-consistency of the diagram and its direct relevance to the results of numerical simulations of the detailed course of enzyme-catalysed reactions.

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