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. 2006 Dec;2(4):283-5.
doi: 10.3988/jcn.2006.2.4.283. Epub 2006 Dec 20.

Downbeat, positional, and perverted head-shaking nystagmus associated with lamotrigine toxicity

Sun-Young Oh  1 , Ji Soo Kim, Young Hoon Lee, Ae Young Lee, Jei Kim, Jae Moon Kim
Affiliations

Downbeat, positional, and perverted head-shaking nystagmus associated with lamotrigine toxicity

Sun-Young Oh et al. J Clin Neurol. 2006 Dec.

Abstract

Lamotrigine is an effective antiepileptic drug with few adverse effects. Nystagmus is one of the commonly observable signs of lamotrigine overdose, which may result from central nervous system involvement. However, the physiologic basis of lamotrigine-induced nystagmus is not fully understood. Here we report a patient who presented with lamotrigine-associated nystagmus that was probably related to cerebellar dysfunction.

Keywords: Downbeat nystagmus; Lamotrigine toxicity; Perverted head-shaking nystagmus.

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Figures

Figure 1
Figure 1
Brain MRI scan showing no evidence of Arnold-Chiari malformation or a discrete lesion in the nodulus or flocculus.
See this image and copyright information in PMC

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