Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jun;36(3):178-81.
doi: 10.4143/crt.2004.36.3.178. Epub 2004 Jun 30.

Predictive value of preoperative serum CEA, CA19-9 and CA125 levels for peritoneal metastasis in patients with gastric carcinoma

Gun Ick Hwang  1 , Chang Hak Yoo, Byung Ho Sohn, Jun Ho Shin, Yong Lai Park, Heung Dai Kim, Yong Shin Kim, Won Kon Han, Won Kil Pae
Affiliations

Predictive value of preoperative serum CEA, CA19-9 and CA125 levels for peritoneal metastasis in patients with gastric carcinoma

Gun Ick Hwang et al. Cancer Res Treat. 2004 Jun.

Abstract

Purpose: Peritoneal metastasis is a crucial factor for the prognosis in gastric cancer, but its diagnosis is difficult before laparotomy. This study analyzed the usefulness of diagnostic imaging and various tumor markers in the detection of peritoneal metastasis in gastric cancer.

Materials and methods: The sera from 768 patients with gastric cancer were measured for CEA, CA19-9 and CA125 levels using a commercial immunoradiometric assay. All the patients underwent diagnostic imaging with computed tomography (CT) and ultrasound (US) before laparotomy.

Results: Preoperative levels of CEA, CA19-9 and CA125 were above the cut-off levels in 15.4%, 8.7% and 5.7% of all cases, respectively. Eighty-eight patients were diagnosed with peritoneal metastasis by laparotomy. CT and US revealed peritoneal dissemination in 15 of 88 patients (17%). Among the three tumor markers, CA19-9 and CA125 showed similar detection rates of peritoneal metastasis (37.5% and 38.6%, respectively). In particular, the serum CA125 levels showed the best sensitivity (38.6%), specificity (98.4%), and diagnostic accuracy (91.5%), and the highest odd ratio (24.46, 95% CI: 11.17 approximately 53.57) for predicting peritoneal metastasis among the markers tested. CEA did not add significant predictive information (p=0.471).

Conclusion: Preoperative serum CA19-9 and CA125 levels may provide a predictable value in determining peritoneal metastasis in patients with gastric cancer.

Keywords: CA125; CA19-9; CEA; Peritoneal metastasis; Stomach neoplasm.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Comparison of diagnostic ability of peritoneal metastasis by each tumor marker. Solid bar: sensitivity; open bar: specificity; shaded bar: diagnostic accuracy. Sensitivity=(patients with peritoneal metastasis with positive tests/all patients with peritoneal metastasis tested) ×100; Specificity=(patients without peritoneal metastasis with negative tests/all patients without peritoneal metastasis tested) ×100; Diagnostic accuracy=(patients with peritoneal metastasis with positive tests+patients without peritoneal metastasis with negative tests)/(all patients tested) ×100.
See this image and copyright information in PMC

References

    1. Bando E, Yonemura Y, Takeshita Y, Taniguchi K, Yasui T, Yoshimitsu Y, Fushida S, Fujimura T, Nishimura G, Miwa K. Intraoperative lavage for cytological examination in 1297 patients with gastric carcinoma. Am J Surg. 1999;178:256–262. - PubMed
    1. Nakata B, Hirakawa K, Kato Y, Yamashita Y, Maeda K, Onoda N, Sawada T, Sowa M. Serum CA125 level as a predictor of peritoneal dissemination in patients with gastric carcinoma. Cancer. 1998;83:2488–2500. - PubMed
    1. Nishiyama M, Takashima I, Tanaka T, Yoshida K, Toge T, Nagata N, Iwamori S, Tamura Y. Carcinoembryonic antigen levels in the peritoneal cavity: useful guide to peritoneal recurrence and prognosis for gastric cancer. World J Surg. 1995;19:133–137. - PubMed
    1. Fujimura T, Ohta T, Kitagawa H, Fushida S, Nishimura GI, Yonemura Y, Elnemr A, Miwa K, Nakamura Y. Trypsinogen expression and early detection for peritoneal dissemination in gastric cancer. J Surg Oncol. 1998;69:71–75. - PubMed
    1. Kodera Y, Yamamura Y, Torii A, Uesaka K, Hirai T, Yasui K, Morimoto T, Kato T, Kito T. The prognostic value of preoperative serum levels of CEA and CA19-9 in patients with gastric cancer. Am J Gastroenterol. 1996;91:49–53. - PubMed

LinkOut - more resources