Cystic fibrosis and Crohn's disease: successful treatment and long term remission with infliximab
- PMID: 20397273
- PMCID: PMC2856836
- DOI: 10.3748/wjg.v16.i15.1924
Cystic fibrosis and Crohn's disease: successful treatment and long term remission with infliximab
Abstract
The association of cystic fibrosis and Crohn's disease (CD) is well known, but to date, there are very few cases in the literature of patients suffering from mucoviscidosis who have required treatment with infliximab. We report the case of a 23-year-old patient suffering from cystic fibrosis and severe CD treated successfully with infliximab without any infective complications or worsening of the pulmonary disease and with a long term (2 years) complete remission.
Keywords: Crohn’s disease; Cystic fibrosis; Infliximab.
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References
-
- Chaudry G, Navarro OM, Levine DS, Oudjhane K. Abdominal manifestations of cystic fibrosis in children. Pediatr Radiol. 2006;36:233–240. - PubMed
-
- Fields TM, Michel SJ, Butler CL, Kriss VM, Albers SL. Abdominal manifestations of cystic fibrosis in older children and adults. AJR Am J Roentgenol. 2006;187:1199–1203. - PubMed
-
- Dobbin CJ, Moriarty C, Bye PT. Granulomatous diseases in a patient with cystic fibrosis. J Cyst Fibros. 2003;2:35–37. - PubMed
-
- Lerner A, Gal N, Mares AJ, Maor E, Iancu TC. Pitfall in diagnosis of Crohn's disease in a cystic fibrosis patient. J Pediatr Gastroenterol Nutr. 1991;12:369–371. - PubMed
-
- Lloyd-Still JD. Crohn's disease and cystic fibrosis. Dig Dis Sci. 1994;39:880–885. - PubMed
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